Back to Search
Start Over
Increased serum interleukin-6 level as a predictive biomarker for atrial fibrillation: A systematic review and meta-analysis
- Source :
- Revista Portuguesa de Cardiologia, Vol 39, Iss 12, Pp 723-728 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Background: Atrial fibrillation (AF) is related to a higher risk of thromboembolic events and mortality. Some studies have demonstrated that the inflammatory biomarker interleukin-6 (IL-6) is associated with a higher risk of higher thrombosis in AF patients, but the real effect of IL-6 remains a controversy. Methods: We conducted a systematic review and meta-analysis to investigate the association between IL-6 and thromboembolic events, as well as bleeding events, acute coronary syndrome (ACS) events and all-cause mortality in AF. Results: A total of five studies involving 22 928 patients met our inclusion criteria for the systematic review. The higher level of IL-6 in AF patients is related to long-term thromboembolic events including stroke (RR 1.44, CI 95% 1.09-1.90, p=0.01). IL-6 meant a higher risk of long-term bleeding risk (RR 1.36, CI 95% 1.06-1.74, p=0.02), ACS risk (RR 1.81, CI 95% 1.43-2.30, p
Details
- Language :
- English, Portuguese
- ISSN :
- 08702551 and 46089101
- Volume :
- 39
- Issue :
- 12
- Database :
- Directory of Open Access Journals
- Journal :
- Revista Portuguesa de Cardiologia
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b7a880b8edcf460891019d7fe57b26dc
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.repc.2020.07.009