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Increased serum interleukin-6 level as a predictive biomarker for atrial fibrillation: A systematic review and meta-analysis

Authors :
Peng Zhou
Maieryemu Waresi
Yikai Zhao
Hung-Chen Lin
Bangwei Wu
Nanqing Xiong
Huiyang Li
Qingyu Huang
Xinping Luo
Jian Li
Source :
Revista Portuguesa de Cardiologia, Vol 39, Iss 12, Pp 723-728 (2020)
Publication Year :
2020
Publisher :
Elsevier, 2020.

Abstract

Background: Atrial fibrillation (AF) is related to a higher risk of thromboembolic events and mortality. Some studies have demonstrated that the inflammatory biomarker interleukin-6 (IL-6) is associated with a higher risk of higher thrombosis in AF patients, but the real effect of IL-6 remains a controversy. Methods: We conducted a systematic review and meta-analysis to investigate the association between IL-6 and thromboembolic events, as well as bleeding events, acute coronary syndrome (ACS) events and all-cause mortality in AF. Results: A total of five studies involving 22 928 patients met our inclusion criteria for the systematic review. The higher level of IL-6 in AF patients is related to long-term thromboembolic events including stroke (RR 1.44, CI 95% 1.09-1.90, p=0.01). IL-6 meant a higher risk of long-term bleeding risk (RR 1.36, CI 95% 1.06-1.74, p=0.02), ACS risk (RR 1.81, CI 95% 1.43-2.30, p

Details

Language :
English, Portuguese
ISSN :
08702551 and 46089101
Volume :
39
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Revista Portuguesa de Cardiologia
Publication Type :
Academic Journal
Accession number :
edsdoj.b7a880b8edcf460891019d7fe57b26dc
Document Type :
article
Full Text :
https://doi.org/10.1016/j.repc.2020.07.009