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Protective effect of Korean red ginseng water extract on levothyroxine-induced hyperthyroidism and propylthiouracil-induced hypothyroidism in rats

Authors :
Lei Huang
Won Young Jang
Ji Hye Yoon
Zhenyan Piao
Jinghan Su
Dong Seon Kim
Ki Woong Kwon
Ji Won Kim
Sang Hee Park
Sunggyu Kim
Jong-Hoon Kim
Jae Youl Cho
Source :
Integrative Medicine Research, Vol 13, Iss 3, Pp 101071- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Background: Korean red ginseng extract (KRGE) (Family: Araliaceae) is one of the most widely used traditional herbs in Asia. Multiple studies have shown that KRGE has anti-inflammation, anti-fatigue, anti-obesity, anti-oxidant, and anti-cancer effects. Methods: Sprague-Dawley rats were divided into five groups for PTU-induced hypothyroidism and six groups for LT4-induced hyperthyroidism. At the experiment's conclusion, rats were sacrificed, and blood, thyroid gland, and liver samples were collected. Body weight was recorded weekly, and serum hormone levels were assessed using enzyme-linked immunoassay. Thyroid gland and liver tissues were stained with hematoxylin and eosin. KRGE was prepared in 0.5% CMC and stored at 4 °C before administration. Results: In the LT4-induced hyperthyroidism model, KRGE prevented decreases in body weight, thyroid gland weight, liver weight, serum glucose, and thyroid hormone levels compared to the PTU group. It also reduced increases in T3, T4, and serum aspartate aminotransferase levels after LT4 treatment. Additionally, KRGE improved thyroid gland and liver histopathology, effects not observed in the PTU-induced hypothyroidism model. Conclusion: All things considered, our research points to KRGE's potential protective role in rat hyperthyroidism caused by LT4 by lowering thyroid hormone production.

Details

Language :
English
ISSN :
22134220
Volume :
13
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Integrative Medicine Research
Publication Type :
Academic Journal
Accession number :
edsdoj.b788e37f2f054fd383abec9684aeb0a6
Document Type :
article
Full Text :
https://doi.org/10.1016/j.imr.2024.101071