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RanBP9 overexpression accelerates loss of dendritic spines in a mouse model of Alzheimer's disease
- Source :
- Neurobiology of Disease, Vol 69, Iss , Pp 169-179 (2014)
- Publication Year :
- 2014
- Publisher :
- Elsevier, 2014.
-
Abstract
- We previously demonstrated that RanBP9 overexpression increased Aβ generation and amyloid plaque burden, subsequently leading to robust reductions in the levels of several synaptic proteins as well as deficits in the learning and memory skills in a mouse model of Alzheimer's disease (AD). In the present study, we found striking reduction of spinophilin-immunoreactive puncta (52%, p
Details
- Language :
- English
- ISSN :
- 1095953X
- Volume :
- 69
- Issue :
- 169-179
- Database :
- Directory of Open Access Journals
- Journal :
- Neurobiology of Disease
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b768ae3adbf34dc39e60b09ac383056f
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.nbd.2014.05.029