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Data set for transcriptional response to depletion of the Shoc2 scaffolding protein
- Source :
- Data in Brief, Vol 7, Iss , Pp 770-778 (2016)
- Publication Year :
- 2016
- Publisher :
- Elsevier, 2016.
-
Abstract
- The Suppressor of Clear, Caenorhabditis elegans Homolog (SHOC2) is a scaffold protein that positively modulates activity of the RAS/ERK1/2 MAP kinase signaling cascade. We set out to understand the ERK1/2 pathway transcriptional response transduced through the SHOC2 scaffolding module. This data article describes raw gene expression within triplicates of kidney fibroblast-like Cos1 cell line expressing non-targeting shRNA (Cos-NT) and triplicates of Cos1 cells depleted of SHOC2 using shRNA (Cos-LV1) upon activation of ERK1/2 pathway by the Epidermal Growth Factor Receptor (EGFR). The data referred here is available in NCBI׳s Gene Expression Omnibus (GEO), accession GEO: GSE67063 as well as NCBI׳s Sequence Read Archive (SRA), accession SRA: SRP056324. A complete analysis of the results can be found in “Shoc2-tranduced ERK1/2 motility signals – Novel insights from functional genomics”(Jeoung et al., 2016) [1].
Details
- Language :
- English
- ISSN :
- 23523409
- Volume :
- 7
- Issue :
- 770-778
- Database :
- Directory of Open Access Journals
- Journal :
- Data in Brief
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b75d814d66eb4b809d76aa0e3f6f7349
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.dib.2016.03.012