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Antiseptic Polymer–Surfactant Complexes with Long-Lasting Activity against SARS-CoV-2
- Source :
- Polymers, Vol 14, Iss 12, p 2444 (2022)
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- Antiseptic polymer gel–surfactant complexes were prepared by incorporating the low-molecular-weight cationic disinfectant cetylpyridinium chloride into the oppositely charged, slightly cross-linked polymer matrices. Three types of polymers were used: copolymers of acrylamide and sodium 2-acrylamido-2-methylpropane sulfonate; copolymers of acrylamide and sodium methacrylate; copolymers of vinylpyrrolidone and sodium methacrylate. It was shown that the rate of the release of the cationic disinfectant from the oppositely charged polymer gels could be tuned in a fairly broad range by varying the concentration of the disinfectant, the degree of swelling, and degree of cross-linking of the gel and the content/type of anionic repeat units in the polymer matrix. Polymer–surfactant complexes were demonstrated to reduce SARS-CoV-2 titer by seven orders of magnitude in as little as 5 s. The complexes retained strong virucidal activity against SARS-CoV-2 for at least one week.
Details
- Language :
- English
- ISSN :
- 20734360
- Volume :
- 14
- Issue :
- 12
- Database :
- Directory of Open Access Journals
- Journal :
- Polymers
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b73572894e0143e9b68cfe944e899ef0
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/polym14122444