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Exploiting endogenous fibrocartilage stem cells to regenerate cartilage and repair joint injury

Authors :
Mildred C. Embree
Mo Chen
Serhiy Pylawka
Danielle Kong
George M. Iwaoka
Ivo Kalajzic
Hai Yao
Chancheng Shi
Dongming Sun
Tzong-Jen Sheu
David A. Koslovsky
Alia Koch
Jeremy J. Mao
Source :
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Publication Year :
2016
Publisher :
Nature Portfolio, 2016.

Abstract

A potentially superior tissue regenerative strategy to stem cell transplantation is modulation of endogenous stem cells. Here the authors show fibrocartilage stem cells exist in the temporomandibular joint that contribute to cartilage regeneration and can be manipulated to enhance regeneration through canonical Wnt signalling.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
7
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.b7252425b434505a45e5bfca648c7a8
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms13073