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Tissue Engineering of the Urethra: From Bench to Bedside

Authors :
Dusan Pastorek
Martina Culenova
Maria Csobonyeiova
Veronika Skuciova
Lubos Danisovic
Stanislav Ziaran
Source :
Biomedicines, Vol 9, Iss 12, p 1917 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Tissue engineering (TE) is a promising approach for repair/substitution of damaged tissues and organs. Urethral strictures are common and serious health conditions that impair quality of life and may lead to serious organ damage. The search for ideal materials for urethral repair has led to interest of scientists and surgeons in urethral TE. Over the last decades, a significant amount of preclinical studies and considerable progress have been observed. In contrast, urethral TE has made slow progress in clinical practice so far. To address this, we conducted a systematic review of the literature on clinical applications of TE constructs for urethral repair in the last three decades. In summary, the TE approach is promising and effective, but many issues remain that need to be addressed for broader adoption of TE in urethral repair. Better design of trials, better cooperation of research groups and centralization could lead to reduction of costs and slowly proceed to commercialization and routine use of TE products for urethral reconstruction.

Details

Language :
English
ISSN :
22279059
Volume :
9
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.b7067cd8b8e74f1f90bd5ba4b2493335
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines9121917