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Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage

Authors :
Zhongbo Chen
David Zhang
Regina H. Reynolds
Emil K. Gustavsson
Sonia García-Ruiz
Karishma D’Sa
Aine Fairbrother-Browne
Jana Vandrovcova
International Parkinson’s Disease Genomics Consortium (IPDGC)
John Hardy
Henry Houlden
Sarah A. Gagliano Taliun
Juan Botía
Mina Ryten
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Knowledge of genomic features specific to humans may be important for understanding disease. Here the authors demonstrate a potential role for these human-lineage-specific sequences in brain development and neurological disease.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.b7017084874dddbf672c99a5595752
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-22262-5