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A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination

Authors :
Karel Miettinen
Nattawat Leelahakorn
Aldo Almeida
Yong Zhao
Lukas R. Hansen
Iben E. Nikolajsen
Jens B. Andersen
Michael Givskov
Dan Staerk
Søren Bak
Sotirios C. Kampranis
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

GPCRs are used for diverse sensing in eukaryotes. Here the authors use GPCRs to construct yeast-based biosensors, focussing on cannabinoids, and use these to screen agonists and antagonists, as well as generate a portable detection device.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723 and 29674689
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.b693c5041f0a2967468996b8660
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-31357-6