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Conceptualisation of an Efficient Particle-Based Simulation of a Twin-Screw Granulator

Authors :
John P. Morrissey
Kevin J. Hanley
Jin Y. Ooi
Source :
Pharmaceutics, Vol 13, Iss 12, p 2136 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Discrete Element Method (DEM) simulations have the potential to provide particle-scale understanding of twin-screw granulators. This is difficult to obtain experimentally because of the closed, tightly confined geometry. An essential prerequisite for successful DEM modelling of a twin-screw granulator is making the simulations tractable, i.e., reducing the significant computational cost while retaining the key physics. Four methods are evaluated in this paper to achieve this goal: (i) develop reduced-scale periodic simulations to reduce the number of particles; (ii) further reduce this number by scaling particle sizes appropriately; (iii) adopt an adhesive, elasto-plastic contact model to capture the effect of the liquid binder rather than fluid coupling; (iv) identify the subset of model parameters that are influential for calibration. All DEM simulations considered a GEA ConsiGmaâ„¢ 1 twin-screw granulator with a 60° rearward configuration for kneading elements. Periodic simulations yielded similar results to a full-scale simulation at significantly reduced computational cost. If the level of cohesion in the contact model is calibrated using laboratory testing, valid results can be obtained without fluid coupling. Friction between granules and the internal surfaces of the granulator is a very influential parameter because the response of this system is dominated by interactions with the geometry.

Details

Language :
English
ISSN :
19994923
Volume :
13
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Pharmaceutics
Publication Type :
Academic Journal
Accession number :
edsdoj.b65a816e409c4e429d8cc3570451cad9
Document Type :
article
Full Text :
https://doi.org/10.3390/pharmaceutics13122136