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RETRACTED ARTICLE: A natural food sweetener with anti-pancreatic cancer properties

Authors :
C Liu
L-H Dai
D-Q Dou
L-Q Ma
Y-X Sun
Source :
Oncogenesis, Vol 5, Iss 4, Pp e217-e217 (2016)
Publication Year :
2016
Publisher :
Nature Publishing Group, 2016.

Abstract

Abstract Mogroside V is a triterpenoid isolated from the traditional Chinese medical plant Siraitia grosvenorii. Mogroside V has a high degree of sweetness and a low calorific content. Herein, we found that mogroside V possesses tumor growth inhibitory activity in in vitro and in vivo models of pancreatic cancer by promoting apoptosis and cell cycle arrest of pancreatic cancer cells (PANC-1 cells), which may in part be mediated through regulating the STAT3 signaling pathway. These results were confirmed in vivo in a mouse xenograft model of pancreatic cancer. In xenograft tumors, Ki-67 and PCNA, the most commonly used markers of tumor cell proliferation, were downregulated after intravenous administration of mogroside V. Terminal deoxynucleotidyl transferase dUTP nick end labeling assays showed that mogroside V treatment promoted apoptosis of pancreatic cancer cells in the xenograft tumors. Furthermore, we found that mogroside V treatment significantly reduced the expression of CD31-labeled blood vessels and of the pro-angiogenic factor vascular endothelial growth factor in the xenografts, indicating that mogroside V might limit the growth of pancreatic tumors by inhibiting angiogenesis and reducing vascular density. These results therefore demonstrate that the natural, sweet-tasting compound mogroside V can inhibit proliferation and survival of pancreatic cancer cells via targeting multiple biological targets.

Details

Language :
English
ISSN :
21579024
Volume :
5
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Oncogenesis
Publication Type :
Academic Journal
Accession number :
edsdoj.b6411769cc26493ab1d33e012113e573
Document Type :
article
Full Text :
https://doi.org/10.1038/oncsis.2016.28