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Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- PAPP-A substrate selectivity underlies the tight regulation of IGF signaling. Here, the authors report cryo-EM structures of dimeric PAPP-A in its substrate-free form and in complex with a peptide substrate, which combined with biochemical assays provide a mechanism for PAPP-A substrate binding and selectivity.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723 and 83342745
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b5c3045813c44acc833427452b1f8434
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-33175-2