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Bacterial PncA improves diet-induced NAFLD in mice by enabling the transition from nicotinamide to nicotinic acid

Authors :
Shengyu Feng
Liuling Guo
Hao Wang
Shanshan Yang
Hailiang Liu
Source :
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Bacterial nicotinamidase/pyrazinamidase PncA increases host nicotinamide adenine dinucleotide (NAD+) levels and ameliorates diet-induced non-alcoholic fatty liver disease (NAFLD) in mice.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.b5322ac5e464d8a903faac99d1a7065
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-023-04613-8