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Powering the Immune System: Mitochondria in Immune Function and Deficiency

Authors :
Melissa A. Walker
Stefano Volpi
Katherine B. Sims
Jolan E. Walter
Elisabetta Traggiai
Source :
Journal of Immunology Research, Vol 2014 (2014)
Publication Year :
2014
Publisher :
Wiley, 2014.

Abstract

Mitochondria are critical subcellular organelles that are required for several metabolic processes, including oxidative phosphorylation, as well as signaling and tissue-specific processes. Current understanding of the role of mitochondria in both the innate and adaptive immune systems is expanding. Concurrently, immunodeficiencies arising from perturbation of mitochondrial elements are increasingly recognized. Recent observations of immune dysfunction and increased incidence of infection in patients with primary mitochondrial disorders further support an important role for mitochondria in the proper function of the immune system. Here we review current findings.

Details

Language :
English
ISSN :
23148861 and 23147156
Volume :
2014
Database :
Directory of Open Access Journals
Journal :
Journal of Immunology Research
Publication Type :
Academic Journal
Accession number :
edsdoj.b51131e2575447809ffcf29ff1acbb7e
Document Type :
article
Full Text :
https://doi.org/10.1155/2014/164309