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Acute Encephalopathy Associated with Influenza A Infection in Adults

Authors :
Nelson Lee
Chun Kwok Wong
Paul K.S. Chan
Niklas Lindegardh
Nicholas J. White
Frederick G. Hayden
Edward H.C. Wong
Ka Shing Wong
Clive S. Cockram
Joseph J.Y. Sung
David S.C. Hui
Source :
Emerging Infectious Diseases, Vol 16, Iss 1, Pp 139-142 (2010)
Publication Year :
2010
Publisher :
Centers for Disease Control and Prevention, 2010.

Abstract

We report acute encephalopathy associated with influenza A infection in 3 adults. We detected high cerebrospinal fluid (CSF) and plasma concentrations of CXCL8/IL-8 and CCL2/MCP-1 (CSF/plasma ratios >3), and interleukin-6, CXCL10/IP-10, but no evidence of viral neuroinvasion. Patients recovered without sequelae. Hyperactivated cytokine response may play a role in pathogenesis.

Details

Language :
English
ISSN :
10806040 and 10806059
Volume :
16
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Emerging Infectious Diseases
Publication Type :
Academic Journal
Accession number :
edsdoj.b4bb3bc4327b4359a1890a2498e068b6
Document Type :
article
Full Text :
https://doi.org/10.3201/eid1601.090077