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Hydroxyapatite crystallinity does not affect the repair of critical size bone defects
- Source :
- Journal of Applied Oral Science, Vol 19, Iss 4, Pp 337-342 (2011)
- Publication Year :
- 2011
- Publisher :
- University of São Paulo, 2011.
-
Abstract
- OBJECTIVE: The physicochemical properties of hydroxyapatite (HA) granules were observed to affect the biological behavior of graft materials. The aim of this work was to analyze the tissue response of two HA granules with different crystallinity and Ca/P ratio in vivo. MATERIAL AND METHODS: The HA granules were produced in the Biomaterials Laboratory (COPPE/UFRJ). The testing materials were HA granules presenting a Ca/P molar ratio of 1.60 and 28% crystallinity (HA-1), and a Ca/P molar ratio of 1.67 and 70% crystallinity (HA-2). Both HAs were implanted into a critical-size calvaria rat defects. RESULTS: To note, in the control group, the bone defects were filled with blood clot only. Descriptive and histomorphometric analyses after 1, 3, and 6 months postoperatively showed mild inflammatory infiltrate, mainly comprising macrophage-like and multinucleated giant cells, and an increase in the volume density of the fibrous tissues (p
- Subjects :
- Hydroxyapatite
Bone grafting
Rats
Histology
Biocompatibility testing
Dentistry
RK1-715
Subjects
Details
- Language :
- English
- ISSN :
- 16787757 and 16787765
- Volume :
- 19
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Applied Oral Science
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b4ae82a3649a435590cd699f4d1aac35
- Document Type :
- article