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Schistosoma mansoni: structural damage after treatment with oxamniquine
- Source :
- Memorias do Instituto Oswaldo Cruz, Vol 82, Pp 347-352 (1987)
- Publication Year :
- 1987
- Publisher :
- Fundação Oswaldo Cruz (FIOCRUZ), 1987.
-
Abstract
- The effects of a single dose (100 mg/kg-body weight of mouse) of oxamniquine on the worm's tegument and paranchyma in relation to the process of immunological granulomatous reaction of the host's liver are described under light and electron microscopy (EM). The lesions caused by the drug are sequentially and simultaneously described in form of swelling, surface bulble and disruption with erosions. Ulceration in the tubercules with loss of spines is often more extensive and severe in male worms and concentration of host's mononuclear cells is observed. The possible role of host's immune response is discussed.
- Subjects :
- Microbiology
QR1-502
Infectious and parasitic diseases
RC109-216
Subjects
Details
- Language :
- English
- ISSN :
- 00740276 and 16788060
- Volume :
- 82
- Database :
- Directory of Open Access Journals
- Journal :
- Memorias do Instituto Oswaldo Cruz
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b46e9659c6ff48c29ff4d5cadef8de4a
- Document Type :
- article
- Full Text :
- https://doi.org/10.1590/S0074-02761987000800067