PI3K Mutation Profiles on Exons 9 (E545K and E542K) and 20 (H1047R) in Mexican Patients With HER-2 Overexpressed Breast Cancer and Its Relevance on Clinical–Pathological and Survival Biological Effects

Conclusion: Single and double-point mutations in PI3K are related to tumor size and advanced clinical–pathological traits in Mexican patients with HER-2 overexpression, and future molecular studies are necessary to understand these findings.