Investigation of the Relationship between the rs8192688 Polymorphism of the FABP-4 Gene and Cardiovascular Disease Susceptibility in Type 2 Diabetic Patients in Ilam Province, Iran

Introduction: Cardiovascular disease (CVD) is the most common cause of death in patients with type 2 diabetes (T2D). The association between diabetes and cardiovascular disease is complex and multifaceted. This study aimed to investigate the possible association between rs8192688 Polymorphism of the FABP-4 gene and the CVD susceptibility in T2DM patients in Ilam Province, Iran. Material & Methods: The statistical population consisted of 210 cases (T2D patients with CVD [n=70], T2D patients without CVD [n=70], and healthy controls [n=70]). The frequency of polymorphisms was investigated using the Tetra-Primer-ARMS-PCR method. (Ethic code: IR.IAU.SHK.1399.011) Findings: The results showed that TG, HDL-C, and LDL-C in the T2D group with CVD were significantly increased, compared to those in the T2D group (P