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An Update of the Promise of Glycine Supplementation for Enhancing Physical Performance and Recovery

Authors :
Arnulfo Ramos-Jiménez
Rosa Patricia Hernández-Torres
David Alfredo Hernández-Ontiveros
Melinna Ortiz-Ortiz
Reymond Josué López-Fregoso
José Miguel Martínez-Sanz
Genaro Rodríguez-Uribe
Marco Antonio Hernández-Lepe
Source :
Sports, Vol 12, Iss 10, p 265 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Glycine, the simple amino acid, is a key component of muscle metabolism with proven cytoprotective effects and hypothetical benefits as a therapeutic nutrient. Cell, in vitro, and animal studies suggest that glycine enhances protection against muscle wasting by activating anabolic pathways and inhibiting proteolytic gene expression. Some evidence indicates that glycine supplementation may enhance peak power output, reduce lactic acid accumulation during high-intensity exercise, and improve sleep quality and recovery. This literature review critically explores glycine’s potential as an ergogenic aid and its relevance to muscle regeneration, muscle strength, endurance exercise performance, and sleep quality. It also underscores key areas for future research. It is concluded that more randomized controlled clinical trials in humans are needed to confirm glycine’s potential as a dietary supplement to support muscle function, recovery, and overall athletic performance as an ergogenic aid and to establish nutritional recommendations for athletic performance. Also, it is essential to consider that high doses (>500 mg/kg of body mass) could induce cytotoxic effects and contribute to acute glutamate toxicity.

Details

Language :
English
ISSN :
20754663
Volume :
12
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Sports
Publication Type :
Academic Journal
Accession number :
edsdoj.b37c98d7746946b1940b595e0bf188e8
Document Type :
article
Full Text :
https://doi.org/10.3390/sports12100265