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Chromosome 20q Amplification Regulates Response to Kinesin-5 Inhibitor
- Source :
- Cancer Informatics, Vol 6 (2008)
- Publication Year :
- 2008
- Publisher :
- SAGE Publishing, 2008.
-
Abstract
- We identified gene expression signatures predicting responsiveness to a Kinesin-5 (KIF11) inhibitor (Kinesin-5i) in cultured colon tumor cell lines. Genes predicting resistance to Kinesin-5i were enriched for those from chromosome 20q, a region of frequent amplification in a number of tumor types. siRNAs targeting genes in this chromosomal region identified AURKA, TPX2 and MYBL2 as genes whose disruption enhances response to Kinesin-5i. Taken together, our results show functional interaction between these genes, and suggest that their overexpression is involved in resistance to Kinesin-5i. Furthermore, our results suggest that patients whose tumors overexpress AURKA due to amplification of 20q will more likely resist treatment with Kinesin-5 inhibitor, and that inactivation of AURKA may sensitize these patients to treatment.
- Subjects :
- Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Subjects
Details
- Language :
- English
- ISSN :
- 11769351
- Volume :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Cancer Informatics
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b372962b62145a69b95174054182e34
- Document Type :
- article
- Full Text :
- https://doi.org/10.4137/CIN.S609