Back to Search Start Over

Comparing approaches for chemoprevention for school-based malaria control in Malawi: an open label, randomized, controlled clinical trialResearch in context

Authors :
Alick Sixpence
Maclean Vokhiwa
Wangisani Kumalakwaanthu
Nicola J. Pitchford
Karl B. Seydel
Laurence S. Magder
Miriam K. Laufer
Don P. Mathanga
Lauren M. Cohee
Source :
EClinicalMedicine, Vol 76, Iss , Pp 102832- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Summary: Background: School-age children in sub-Saharan Africa suffer an underappreciated burden of malaria which threatens their health and education. To address this problem, we compared the efficacy of two school-based chemoprevention approaches: giving all students intermittent preventive treatment (IPT) or screening and treating only students with detected infections (IST). Methods: In a three-arm, open-label, randomized, controlled trial (NCT05244954) in Malawi, 746 primary school students, aged 5–19 years, were individually randomized within each grade-level to IPT (n = 249), IST with a high-sensitivity rapid diagnostic test (hs-RDT, n = 248), or control (n = 249). At six-week intervals three times within the peak malaria transmission season (February–June 2022) treatment with dihydroartemisinin-piperaquine (DP) was administered to girls

Details

Language :
English
ISSN :
25895370
Volume :
76
Issue :
102832-
Database :
Directory of Open Access Journals
Journal :
EClinicalMedicine
Publication Type :
Academic Journal
Accession number :
edsdoj.b3614624e5764f9889b00f2da1d26206
Document Type :
article
Full Text :
https://doi.org/10.1016/j.eclinm.2024.102832