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Comparing approaches for chemoprevention for school-based malaria control in Malawi: an open label, randomized, controlled clinical trialResearch in context
- Source :
- EClinicalMedicine, Vol 76, Iss , Pp 102832- (2024)
- Publication Year :
- 2024
- Publisher :
- Elsevier, 2024.
-
Abstract
- Summary: Background: School-age children in sub-Saharan Africa suffer an underappreciated burden of malaria which threatens their health and education. To address this problem, we compared the efficacy of two school-based chemoprevention approaches: giving all students intermittent preventive treatment (IPT) or screening and treating only students with detected infections (IST). Methods: In a three-arm, open-label, randomized, controlled trial (NCT05244954) in Malawi, 746 primary school students, aged 5–19 years, were individually randomized within each grade-level to IPT (n = 249), IST with a high-sensitivity rapid diagnostic test (hs-RDT, n = 248), or control (n = 249). At six-week intervals three times within the peak malaria transmission season (February–June 2022) treatment with dihydroartemisinin-piperaquine (DP) was administered to girls
Details
- Language :
- English
- ISSN :
- 25895370
- Volume :
- 76
- Issue :
- 102832-
- Database :
- Directory of Open Access Journals
- Journal :
- EClinicalMedicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b3614624e5764f9889b00f2da1d26206
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.eclinm.2024.102832