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Therapeutic Potential of Dopamine and Related Drugs as Anti-Inflammatories and Antioxidants in Neuronal and Non-Neuronal Pathologies

Authors :
Cindy Bandala
Noemi Cárdenas-Rodríguez
Julieta Griselda Mendoza-Torreblanca
Itzel Jatziri Contreras-García
Valentín Martínez-López
Teresita Rocio Cruz-Hernández
Jazmín Carro-Rodríguez
Marco Antonio Vargas-Hernández
Iván Ignacio-Mejía
Alfonso Alfaro-Rodriguez
Eleazar Lara-Padilla
Source :
Pharmaceutics, Vol 15, Iss 2, p 693 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Dopamine (DA), its derivatives, and dopaminergic drugs are compounds widely used in the management of diseases related to the nervous system. However, DA receptors have been identified in nonneuronal tissues, which has been related to their therapeutic potential in pathologies such as sepsis or septic shock, blood pressure, renal failure, diabetes, and obesity, among others. In addition, DA and dopaminergic drugs have shown anti-inflammatory and antioxidant properties in different kinds of cells. Aim: To compile the mechanism of action of DA and the main dopaminergic drugs and show the findings that support the therapeutic potential of these molecules for the treatment of neurological and non-neurological diseases considering their antioxidant and anti-inflammatory actions. Method: We performed a review article. An exhaustive search for information was carried out in specialized databases such as PubMed, PubChem, ProQuest, EBSCO, Scopus, Science Direct, Web of Science, Bookshelf, DrugBank, Livertox, and Clinical Trials. Results: We showed that DA and dopaminergic drugs have emerged for the management of neuronal and nonneuronal diseases with important therapeutic potential as anti-inflammatories and antioxidants. Conclusions: DA and DA derivatives can be an attractive treatment strategy and a promising approach to slowing the progression of disorders through repositioning.

Details

Language :
English
ISSN :
19994923
Volume :
15
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Pharmaceutics
Publication Type :
Academic Journal
Accession number :
edsdoj.b333d2900194fe1b4964c4c568c3d1a
Document Type :
article
Full Text :
https://doi.org/10.3390/pharmaceutics15020693