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Noninvasive urinary protein signatures associated with colorectal cancer diagnosis and metastasis

Authors :
Yulin Sun
Zhengguang Guo
Xiaoyan Liu
Lijun Yang
Zongpan Jing
Meng Cai
Zhaoxu Zheng
Chen Shao
Yefan Zhang
Haidan Sun
Li Wang
Minjie Wang
Jun Li
Lusong Tian
Yue Han
Shuangmei Zou
Jiajia Gao
Yan Zhao
Peng Nan
Xiufeng Xie
Fang Liu
Lanping Zhou
Wei Sun
Xiaohang Zhao
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

More sensitive and specific non-invasive biomarkers are desired for early detection of cancer. Here, the authors show a protein signature in the urine that increases sensitivity for colorectal cancer detection when combined with fecal immunochemical tests and corrects diagnosis in some fecal immunochemical tests-negative patients.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.b3247a8cb6d43b5bf522777e805b002
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-30391-8