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Protective Effects from Prior Pneumococcal Vaccination in Patients with Chronic Airway Diseases during Hospitalization for Influenza—A Territory-Wide Study

Authors :
Wang-Chun Kwok
David Christopher Lung
Terence Chi-Chun Tam
Desmond Yat-Hin Yap
Ting-Fung Ma
Chung-Ki Tsui
Ru Zhang
David Chi-Leung Lam
Mary Sau-Man Ip
James Chung-Man Ho
Source :
Vaccines, Vol 12, Iss 7, p 704 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Influenza is an important respiratory viral pathogen in adults, with secondary bacterial pneumonia being a common complication. While pneumococcal vaccines can prevent pneumococcal pneumonia and invasive pneumococcal disease, whether they can also prevent the severe in-hospital outcomes among patients hospitalized for influenza has not been examined. A territory-wide retrospective study was conducted in Hong Kong, which included all adult patients having chronic airway diseases (asthma, bronchiectasis, and chronic obstructive pulmonary disease) hospitalized for influenza and who had received seasonal influenza vaccine. The occurrence of secondary bacterial pneumonia, mortality, and other severe in-hospital outcomes were compared among subjects with or without pneumococcal vaccination. There was a total of 3066 eligible patients who were hospitalized for influenza in public hospitals in Hong Kong from 1 January 2016 to 30 June 2023. Completed pneumococcal vaccination with PSV23/PCV13 conferred protection against secondary bacterial pneumonia, all-cause mortality, and respiratory cause of mortality with adjusted odds ratios of 0.74 (95% CI = 0.57–0.95, p = 0.019), 0.12 (95% CI = 0.03–0.53, p = 0.005), and 0.04 (95% CI = 0.00–0.527, p = 0.0038), respectively.

Details

Language :
English
ISSN :
2076393X
Volume :
12
Issue :
7
Database :
Directory of Open Access Journals
Journal :
Vaccines
Publication Type :
Academic Journal
Accession number :
edsdoj.b2c7b777e8f9495fabc44d5db8d3055e
Document Type :
article
Full Text :
https://doi.org/10.3390/vaccines12070704