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Egg-laying and locomotory screens with C. elegans yield a nematode-selective small molecule stimulator of neurotransmitter release

Authors :
Sean Harrington
Jessica J. Knox
Andrew R. Burns
Ken-Loon Choo
Aaron Au
Megan Kitner
Cecile Haeberli
Jacob Pyche
Cassandra D’Amata
Yong-Hyun Kim
Jonathan R. Volpatti
Maximillano Guiliani
Jamie Snider
Victoria Wong
Bruna M. Palmeira
Elizabeth M. Redman
Aditya S. Vaidya
John S. Gilleard
Igor Stagljar
Sean R. Cutler
Daniel Kulke
James J. Dowling
Christopher M. Yip
Jennifer Keiser
Inga Zasada
Mark Lautens
Peter J. Roy
Source :
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

A C. elegans-based screening approach identifies nementin as a nematode-selective nematicide that can be used synergistically with acetylcholinesterase inhibitors

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
5
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.b2ae40e60cd44727b137593ac69b190f
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-022-03819-6