Back to Search Start Over

Transmission of pancreatic adenocarcinoma by a single multiorgan donor to two kidney transplant recipients: A case report

Authors :
Tanja Belčič Mikič
Gregor Mlinšek
Manca Oblak
Aljoša Kandus
Jadranka Buturović-Ponikvar
Simon Hawlina
Tomaž Milanez
Nika Kojc
Maja Frelih
Miha Arnol
Source :
Frontiers in Medicine, Vol 10 (2023)
Publication Year :
2023
Publisher :
Frontiers Media S.A., 2023.

Abstract

We present two cases of transmission of a pancreatic adenocarcinoma from a single donor to two kidney transplant recipients. Autopsy of the donor revealed a pancreatic adenocarcinoma that had already spread locally to the regional lymph nodes and had not been detected at the time of organ procurement. Both recipients were carefully monitored, as neither consented to graft nephrectomy. In one patient, the tumor was discovered on surveillance biopsy of the graft approximately 14 months after transplantation, and in the second patient, ultrasound-guided aspiration needle biopsy of a growing formation in the lower pole of the graft revealed poorly differentiated metastatic adenocarcinoma. Both patients were successfully treated with graft nephrectomy and complete discontinuation of immunosuppression. None of the follow-up imaging showed persistent or recurrent malignancy, and both patients were candidates for re-transplantation. These exceptional cases of donor-derived pancreatic adenocarcinoma suggest that removal of the donor organ and restoration of immunity may lead to complete recovery.

Details

Language :
English
ISSN :
2296858X
Volume :
10
Database :
Directory of Open Access Journals
Journal :
Frontiers in Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.b29c832f1bec4ecf8c84ba066c9e1a2a
Document Type :
article
Full Text :
https://doi.org/10.3389/fmed.2023.1142611