Progress of angiotensin converting enzyme 2 in cardiovascular diseases

Authors :: JIAO Xiao-lu, QIN Yan-wen
Source :: Jichu yixue yu linchuang, Vol 40, Iss 5, Pp 701-706 (2020)
Publication Year :: 2020
Publisher :: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College., 2020.
Abstract: Angiotensin-converting enzyme 2 (ACE2) is the receptor for SARS-CoV and SARS-CoV-2(severe acute respiratory syndrom coronavirus 2) viruses, and it is also one of the main family members of renin-angiotensin-aldosterone system. ACE2 has a protective effect on cardiovascular diseases and inhibits the development of cardiovascular diseases. SARS-CoV-2 reduces the expression of ACE2 of host, which may be one of the reasons for cardiovascular complications in the later stage of coronavirus disease 2019(COVID-19). Thus, the role and mechanism of ACE2 in the development of cardiovascular diseases were summarized in this article in order to provide potential stratigy development for the treatment of COVID-19.