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Sarcomatoid variant urothelial carcinoma of the bladder: a systematic review and meta-analysis of the clinicopathological features and survival outcomes

Authors :
Liangyou Gu
Qing Ai
Qiang Cheng
Xin Ma
Baojun Wang
Qingbo Huang
Xintao Li
Peng Zhang
Kan Liu
Xupeng Zhao
Hongzhao Li
Xu Zhang
Source :
Cancer Cell International, Vol 20, Iss 1, Pp 1-14 (2020)
Publication Year :
2020
Publisher :
BMC, 2020.

Abstract

Abstract Background A systematic review and meta-analysis was performed to compare the clinicopathological features and survival outcomes between sarcomatoid variant (SV)-urothelial carcinoma of the bladder (UCB) and conventional UCB (C-UCB). Methods A comprehensive search of PubMed, Embase, and Cochrane Library was performed. Endpoints included clinicopathological features and survival outcomes (overall survival [OS], cancer-specific survival [CSS], and progression-free survival [PFS]). The survival benefits of neoadjuvant chemotherapy (NAC) or adjuvant chemotherapy (AC) for SV-UCB also have been studied. Results A total of 8 observational studies were included. Patients with SV-UCB had a higher rate of ≥ stage pT3 (odds ratio [OR], 2.06; 95% confidence interval [CI], 1.64–2.59; p

Details

Language :
English
ISSN :
14752867
Volume :
20
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Cancer Cell International
Publication Type :
Academic Journal
Accession number :
edsdoj.b1fc98e8a83243c3896d1f88f0638bb1
Document Type :
article
Full Text :
https://doi.org/10.1186/s12935-020-01626-9