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Detection of photoreceptor disruption by adaptive optics fundus imaging and Fourier-domain optical coherence tomography in eyes with occult macular dystrophy
- Source :
- Clinical Ophthalmology, Vol 2011, Iss default, Pp 345-351 (2011)
- Publication Year :
- 2011
- Publisher :
- Dove Medical Press, 2011.
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Abstract
- Yoshiyuki Kitaguchi1, Shunji Kusaka1, Tatsuo Yamaguchi2, Toshifumi Mihashi2, Takashi Fujikado11Department of Applied Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan; 2Topcon Research Institute, Itabashi, JapanPurpose: To investigate the structural changes in the photoreceptors by adaptive optics (AO) fundus imaging and Fourier-domain optical coherence tomography (FD-OCT) in eyes with occult macular dystrophy (OMD).Design: Observational case reports.Methods: Eight eyes of four patients who were diagnosed with OMD were examined. All eyes had a complete ophthalmological examination. Multifocal electroretinograms (mfERGs) were recorded from all eyes. AO and FD-OCT images of foveal photoreceptors were obtained.Results: The best-corrected visual acuity (BCVA) of these eyes ranged from 20/20 to 20/200, and the ocular fundus was normal by conventional ocular examination in all eyes. The amplitudes of the mfERGs were decreased in the foveal area. The inner and outer segment (IS/OS) junction of the photoreceptors in the foveal area was disrupted. The IS/OS junction was intact in one eye with a BCVA of 20/20, and the outer segment layer between the IS/OS junction and retinal pigment epithelium of the FD-OCT images was identified only in the center of the fovea. The AO images showed patchy dark areas in all eyes, which indicated a disruption of the mosaic of bright spots in the fovea.Conclusion: Structural changes of photoreceptors in OMD patients were detected tangentially by FD-OCT and en face by AO.Keywords: Photoreceptors, OMD, images, retinal imaging
- Subjects :
- Ophthalmology
RE1-994
Subjects
Details
- Language :
- English
- ISSN :
- 11775467 and 11775483
- Volume :
- 2011
- Issue :
- default
- Database :
- Directory of Open Access Journals
- Journal :
- Clinical Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b12d3ca542467db01fa6272070405e
- Document Type :
- article