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Diagnostic and Prognostic Performance of MicroRNA-25, Carbohydrate Antigen 19-9, Carcinoembryonic Antigen, and Carbohydrate Antigen 125 in Pancreatic Ductal Adenocarcinoma

Authors :
Yan Gong
Lele Song
Lei Ou
You-Yong Lu
Xianyong Huang
Qiang Zeng
Source :
Iranian Journal of Medical Sciences, Vol 48, Iss 4, Pp 401-413 (2023)
Publication Year :
2023
Publisher :
Shiraz University of Medical Sciences, 2023.

Abstract

Background: Pancreatic cancer is a malignancy with high mortality due to the difficulties in early detection. We investigated and compared the diagnostic and prognostic performance of several blood biomarkers, including microRNA-25 (miR-25), carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA), and carbohydrate antigen 125 (CA125). Methods: A retrospective study was conducted at the Chinese People’s Liberation Army General Hospital from May 2014 to September 2018. Serum specimens were collected, and miR-25 expression levels were measured using real-time quantitative polymerase chain reaction. Serum CA19-9, CEA, and CA125 levels were measured using enzyme-linked immunosorbent assay (ELISA). Statistical analyses including nonparametric test, receiver operator characteristic (ROC) curves, Kaplan-Meier analysis, and subsequent log-rank test were performed with PRISM 5.0 software. Univariate and multivariate analyses were performed with the R software. P

Details

Language :
English
ISSN :
02530716 and 17353688
Volume :
48
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Iranian Journal of Medical Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.b0f5a288e44c41f88e1150312c34ad56
Document Type :
article
Full Text :
https://doi.org/10.30476/ijms.2022.95583.2705