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Diagnostic and Prognostic Performance of MicroRNA-25, Carbohydrate Antigen 19-9, Carcinoembryonic Antigen, and Carbohydrate Antigen 125 in Pancreatic Ductal Adenocarcinoma
- Source :
- Iranian Journal of Medical Sciences, Vol 48, Iss 4, Pp 401-413 (2023)
- Publication Year :
- 2023
- Publisher :
- Shiraz University of Medical Sciences, 2023.
-
Abstract
- Background: Pancreatic cancer is a malignancy with high mortality due to the difficulties in early detection. We investigated and compared the diagnostic and prognostic performance of several blood biomarkers, including microRNA-25 (miR-25), carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA), and carbohydrate antigen 125 (CA125). Methods: A retrospective study was conducted at the Chinese People’s Liberation Army General Hospital from May 2014 to September 2018. Serum specimens were collected, and miR-25 expression levels were measured using real-time quantitative polymerase chain reaction. Serum CA19-9, CEA, and CA125 levels were measured using enzyme-linked immunosorbent assay (ELISA). Statistical analyses including nonparametric test, receiver operator characteristic (ROC) curves, Kaplan-Meier analysis, and subsequent log-rank test were performed with PRISM 5.0 software. Univariate and multivariate analyses were performed with the R software. P
- Subjects :
- pancreatic neoplasm
pdac
screening
microrna
adenocarcinoma
Medicine (General)
R5-920
Subjects
Details
- Language :
- English
- ISSN :
- 02530716 and 17353688
- Volume :
- 48
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Iranian Journal of Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b0f5a288e44c41f88e1150312c34ad56
- Document Type :
- article
- Full Text :
- https://doi.org/10.30476/ijms.2022.95583.2705