The role disorders at system of cytokines in pathogenesis of Helicobacter pilory-associated pathology

Fifty five Khakas people with Helicobacter pylori-associated ulcer disease and chronic gastritis were examined in order to estimate the production of IL-2, IL-4, and IL-10 interleukins in patients with chronic Helicobacter pylori persistence. The subpopulation composition of lymphocytes of peripheral blood was determined by the method of flow-through cytofluorometry. Apoptosis was estimated by the method of optical microscopy. The IL-2, IL-4, IL-10 production in supernatants was determined by the solidphase immunoenzymometric method. Changes revealed in the blood of patients infected with Helicobacter pylori were characterized by the increased amount and subpopulation disbalance of lymphocytes, apoptosis modification, and depletion of lymphocyte functional activity.