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Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis

Authors :
Natalia Jarzebska
Ekaterina S. Karetnikova
Alexander G. Markov
Michael Kasper
Roman N. Rodionov
Peter M. Spieth
Source :
Frontiers in Medicine, Vol 7 (2021)
Publication Year :
2021
Publisher :
Frontiers Media S.A., 2021.

Abstract

Radiation-induced pulmonary fibrosis is a common severe long-time complication of radiation therapy for tumors of the thorax. Current therapeutic options used in the clinic include only supportive managements strategies, such as anti-inflammatory treatment using steroids, their efficacy, however, is far from being satisfactory. Recent studies have demonstrated that the development of lung fibrosis is a dynamic and complex process, involving the release of reactive oxygen species, activation of Toll-like receptors, recruitment of inflammatory cells, excessive production of nitric oxide and production of collagen by activated myofibroblasts. In this review we summarized the current state of knowledge on the pathophysiological processes leading to the development of lung fibrosis and we also discussed the possible treatment options.

Details

Language :
English
ISSN :
2296858X
Volume :
7
Database :
Directory of Open Access Journals
Journal :
Frontiers in Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.b0d77ff2c4b01a888e45855c039ad
Document Type :
article
Full Text :
https://doi.org/10.3389/fmed.2020.585756