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Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error

Authors :
Qiao Fan
Virginie J. M. Verhoeven
Robert Wojciechowski
Veluchamy A. Barathi
Pirro G. Hysi
Jeremy A. Guggenheim
René Höhn
Veronique Vitart
Anthony P. Khawaja
Kenji Yamashiro
S Mohsen Hosseini
Terho Lehtimäki
Yi Lu
Toomas Haller
Jing Xie
Cécile Delcourt
Mario Pirastu
Juho Wedenoja
Puya Gharahkhani
Cristina Venturini
Masahiro Miyake
Alex W. Hewitt
Xiaobo Guo
Johanna Mazur
Jenifer E. Huffman
Katie M. Williams
Ozren Polasek
Harry Campbell
Igor Rudan
Zoran Vatavuk
James F. Wilson
Peter K. Joshi
George McMahon
Beate St Pourcain
David M. Evans
Claire L. Simpson
Tae-Hwi Schwantes-An
Robert P. Igo
Alireza Mirshahi
Audrey Cougnard-Gregoire
Céline Bellenguez
Maria Blettner
Olli Raitakari
Mika Kähönen
Ilkka Seppälä
Tanja Zeller
Thomas Meitinger
Janina S. Ried
Christian Gieger
Laura Portas
Elisabeth M. van Leeuwen
Najaf Amin
André G. Uitterlinden
Fernando Rivadeneira
Albert Hofman
Johannes R. Vingerling
Ya Xing Wang
Xu Wang
Eileen Tai-Hui Boh
M. Kamran Ikram
Charumathi Sabanayagam
Preeti Gupta
Vincent Tan
Lei Zhou
Candice E. H. Ho
Wan’e Lim
Roger W. Beuerman
Rosalynn Siantar
E-Shyong Tai
Eranga Vithana
Evelin Mihailov
Chiea-Chuen Khor
Caroline Hayward
Robert N. Luben
Paul J. Foster
Barbara E. K. Klein
Ronald Klein
Hoi-Suen Wong
Paul Mitchell
Andres Metspalu
Tin Aung
Terri L. Young
Mingguang He
Olavi Pärssinen
Cornelia M. van Duijn
Jie Jin Wang
Cathy Williams
Jost B. Jonas
Yik-Ying Teo
David A. Mackey
Konrad Oexle
Nagahisa Yoshimura
Andrew D. Paterson
Norbert Pfeiffer
Tien-Yin Wong
Paul N. Baird
Dwight Stambolian
Joan E. Bailey Wilson
Ching-Yu Cheng
Christopher J. Hammond
Caroline C. W. Klaver
Seang-Mei Saw
Consortium for Refractive Error and Myopia (CREAM)
Source :
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Publication Year :
2016
Publisher :
Nature Portfolio, 2016.

Abstract

This report by the Consortium for Refractive Error and Myopia uses gene-environment-wide interaction study (GEWIS) to identify genetic loci that affect environmental influence in myopia development, and identifies ethnic specific genetic loci that attribute to eye refractive errors.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
7
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.b0563139c510416e9a4da61510e1f5d4
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms11008