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Effects of Treadmill Exercise on Autistic Behavior and Prefrontal Cortical SHANK Receptors in Autism Spectrum Disorder Model Mice

Authors :
Kyeong-Ri Kim
Tae-Kyung Kim
Joon-Yong Cho
Source :
운동과학, Vol 33, Iss 1, Pp 46-55 (2024)
Publication Year :
2024
Publisher :
The Korean Society of Exercise Physiology, 2024.

Abstract

PURPOSE The first aim of this study is to change autistic behavior in Shank3B Knock-Out (KO) mice through treadmill exercise (TD), and the second aim is to alter SHANK protein receptors in the prefrontal cortex (PFC) of mice through TD. METHODS Male mice were divided into Control (11-week-old, n=8), Control+TD (n=8), Shank3B KO (n=8), and Shank3B KO+TD (n=8). Control and Shank3B KO mice were exercised using TD for 2 weeks for 30 minutes each to observe the effects of exercise. RESULTS Compared to the control group (C57BL/6J), Shank3B KO mice showed excessive self-grooming behavior; however, TD reduced repetitive behavior (p

Details

Language :
Korean
ISSN :
12261726 and 23840544
Volume :
33
Issue :
1
Database :
Directory of Open Access Journals
Journal :
운동과학
Publication Type :
Academic Journal
Accession number :
edsdoj.b01c64778d8643e6ab19267bd7f8fb9d
Document Type :
article
Full Text :
https://doi.org/10.15857/ksep.2024.00087