EGFR mutations are significantly associated with visceral pleural invasion development in non-small-cell lung cancer patients

Jinghan Shi, Yang Yang, Yanfeng Zhao, Junjie Zhu, Xiao Song, Gening Jiang Department of Thoracic Surgery, Shanghai Pulmonary Hospital affiliated to Tongji University, Shanghai, China Objectives: A retrospective study was performed to investigate the association between EGFR mutations and visceral pleural invasion (VPI), and evaluate the prognostic value of EGFR in resected non-small-cell lung cancer (NSCLC) patients with VPI.Materials and methods: Clinicopathological characteristics and follow-up information were collected from 508 consecutive patients with surgically resected stage I–III NSCLC, and EGFR mutations were detected based on real-time PCR technology. Significant results (P