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Early and late recurrences in lymph node-negative gastric cancer: a retrospective cohort study

Early and late recurrences in lymph node-negative gastric cancer: a retrospective cohort study

Authors :
Jian-Wei Sun
Dao-Li Liu
Jia-Xian Chen
Li-Zhen Lin
Lv-Ping Zhuang
Xian-Hai Hou
Source :
Annals of Saudi Medicine, Vol 41, Iss 6, Pp 336-349 (2021)
Publication Year :
2021
Publisher :
King Faisal Specialist Hospital and Research Centre, 2021.

Abstract

BACKGROUND: Predictors of recurrence in patients with lymph node-negative gastric cancer (GC) who have undergone curative resection have been widely investigated, but not the effects of predictors on timing of recurrence. OBJECTIVE: Determine the factors associated with early and late recurrence in patients with node-negative GC. DESIGN: Retrospective cohort. SETTING: Academic tertiary care center. PATIENTS AND METHODS: The study included patients with node-negative GC after curative resection between 2008 and 2018 at two institutions. Early and late recurrences were determined using a minimum P value approach to evaluate the optimal cutoff for recurrence-free survival (RFS). A competing risk model and landmark analysis were used to analyze factors associated with early and late recurrences. MAIN OUTCOME MEASURES: Recurrence-free survival and factors associated with survival. SAMPLE SIZE: 606. RESULTS: After a median follow-up of 70 months, 50 (8.3%) patients experienced recurrent disease. The optimal length of RFS for distinguishing between early (n=26) and late recurrence (n=24) was 24 months (P=.0013). The median RFS in the early and late recurrence groups was 11 and 32 months, respectively. Diffuse tumors (hazard ratio 3.358, P=.014), advanced T stage (HR 8.804, P=.003), perineural invasion (HR 10.955, P

Subjects

Subjects :
Medicine

Details

Language :
English
ISSN :
02564947 and 09754466
Volume :
41
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Annals of Saudi Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.9f66bc16afc4c26b72915865f8dabe5
Document Type :
article
Full Text :
https://doi.org/10.5144/0256-4947.2021.336