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Early and late recurrences in lymph node-negative gastric cancer: a retrospective cohort study
Early and late recurrences in lymph node-negative gastric cancer: a retrospective cohort study
- Source :
- Annals of Saudi Medicine, Vol 41, Iss 6, Pp 336-349 (2021)
- Publication Year :
- 2021
- Publisher :
- King Faisal Specialist Hospital and Research Centre, 2021.
-
Abstract
- BACKGROUND: Predictors of recurrence in patients with lymph node-negative gastric cancer (GC) who have undergone curative resection have been widely investigated, but not the effects of predictors on timing of recurrence. OBJECTIVE: Determine the factors associated with early and late recurrence in patients with node-negative GC. DESIGN: Retrospective cohort. SETTING: Academic tertiary care center. PATIENTS AND METHODS: The study included patients with node-negative GC after curative resection between 2008 and 2018 at two institutions. Early and late recurrences were determined using a minimum P value approach to evaluate the optimal cutoff for recurrence-free survival (RFS). A competing risk model and landmark analysis were used to analyze factors associated with early and late recurrences. MAIN OUTCOME MEASURES: Recurrence-free survival and factors associated with survival. SAMPLE SIZE: 606. RESULTS: After a median follow-up of 70 months, 50 (8.3%) patients experienced recurrent disease. The optimal length of RFS for distinguishing between early (n=26) and late recurrence (n=24) was 24 months (P=.0013). The median RFS in the early and late recurrence groups was 11 and 32 months, respectively. Diffuse tumors (hazard ratio 3.358, P=.014), advanced T stage (HR 8.804, P=.003), perineural invasion (HR 10.955, P
- Subjects :
- Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 02564947 and 09754466
- Volume :
- 41
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Annals of Saudi Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9f66bc16afc4c26b72915865f8dabe5
- Document Type :
- article
- Full Text :
- https://doi.org/10.5144/0256-4947.2021.336