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HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy
- Source :
- Translational Oncology, Vol 9, Iss 2, Pp 99-107 (2016)
- Publication Year :
- 2016
- Publisher :
- Elsevier, 2016.
-
Abstract
- Neoplastic growth is frequently associated with genomic DNA methylation that causes transcriptional silencing of tumor suppressor genes. We used a collection of colorectal polyps and carcinomas in combination with bioinformatics analysis of large datasets to study the expression and methylation of Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene inactivated in many neoplasms. In premalignant stages, HIC1 expression was decreased, and the decrease was linked to methylation of a specific region in the HIC1 locus. However, in carcinomas, the HIC1 expression was variable and, in some specimens, comparable to healthy tissue. Importantly, high HIC1 production distinguished a specific type of chemotherapy-responsive tumors.
- Subjects :
- Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Subjects
Details
- Language :
- English
- ISSN :
- 19365233 and 19447124
- Volume :
- 9
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Translational Oncology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9f1b1d985a2d49578ef07e9ef602a819
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.tranon.2016.01.005