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Vitamin D status of Arab Gulf residents screened for SARS-CoV-2 and its association with COVID-19 infection: a multi-centre case–control study

Authors :
Nasser M. Al-Daghri
Osama E. Amer
Naif H. Alotaibi
Dara A. Aldisi
Mushira A. Enani
Eman Sheshah
Naji J. Aljohani
Naemah Alshingetti
Suliman Y. Alomar
Hanan Alfawaz
Syed D. Hussain
Abdullah M. Alnaami
Shaun Sabico
Source :
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-8 (2021)
Publication Year :
2021
Publisher :
BMC, 2021.

Abstract

Abstract Objectives Vitamin D status in patients with COVID-19 is an on-going controversial issue. This study aims to determine differences in the serum 25(OH)D concentrations of Arab Gulf adult residents screened for SARS-CoV-2 and its association with risk of COVID-19 infection together with other comorbidities. Methods In this multi-center, case–control study, a total of 220 male and female adults presenting with none to mild symptoms were screened for COVID-19 (n = 138 RT-PCR-confirmed SARS-CoV-2 positive and 82 negative controls). Medical history was noted. Anthropometrics were measured and non-fasting blood samples were collected for the assessment of glucose, lipids, inflammatory markers and serum 25(OH)D concentrations. Results Serum 25(OH)D levels were significantly lower in the SARS-CoV-2 positive group compared to the negative group after adjustment for age and BMI (52.8 nmol/l ± 11.0 versus 64.5 nmol/l ± 11.1; p = 0.009). Being elderly (> 60 years) [Odds ratio 6 (95% Confidence Interval, CI 2–18; p = 0.001) as well as having type 2 diabetes (T2D) [OR 6 (95% CI 3–14); p

Details

Language :
English
ISSN :
14795876
Volume :
19
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Translational Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.9f0db186ab164fec82e464a3ca40de2e
Document Type :
article
Full Text :
https://doi.org/10.1186/s12967-021-02838-x