Clinical Analysis and Risk Factors of Bronchiolitis Obliterans After Mycoplasma Pneumoniae Pneumonia

Hao-Qi Zheng,1 Yu-Cong Ma,1 Yu-Quan Chen,2 Yan-Yue Xu,1 Yan-Lin Pang,1 Li Liu1 1Department of Pediatrics, The First Hospital of Jilin University, Changchun, 130021, People’s Republic of China; 2Institute of Medical Information/Library, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100020, People’s Republic of ChinaCorrespondence: Li Liu, Department of Pediatrics, The First Hospital of Jilin University, Changchun, 130021, People’s Republic of China, Email lli01@jlu.edu.cnPurpose: Severe mycoplasma pneumoniae (MP) pneumonia can cause bronchiolitis obliterans (BO). In order to improve the prognosis of BO, it is necessary to grasp the clinical characteristics and risk factors of BO after severe MP pneumonia and intervene as soon as possible.Patients and Methods: This study retrospectively analyzed the clinical data of 110 patients with severe MP pneumonia, and divided them into BO group (22 cases) and non-BO group (88 cases). The clinical characteristics of BO group were analyzed, and the clinical data of two groups were compared to identify the risk factors of BO.Results: At the time of diagnosis, all BO patients had symptoms of cough and wheezing, and 10 (45.45%) had decreased exercise intolerance. Lung function showed moderate to severe obstructive ventilatory dysfunction, high-resolution computed tomography (HRCT) showed mosaic perfusion patterns. Multivariate binomial regression analysis showed that higher levels of serum lactate dehydrogenase (LDH) and hypoxemia were independent risk factors for BO after severe MP pneumonia.Conclusion: Higher levels of serum LDH and hypoxemia were independent risk factors for BO after severe MP pneumonia. For patients with risk factors, clinicians should regular follow-up for early diagnosis and intervention of BO.Keywords: children, bronchiolitis obliterans, mycoplasma pneumoniae pneumonia, post-infectious bronchiolitis obliterans, risk factors