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Everolimus-eluting stents: update on current clinical studies
- Source :
- Medical Devices: Evidence and Research, Vol 2011, Iss default, Pp 91-98 (2011)
- Publication Year :
- 2011
- Publisher :
- Dove Medical Press, 2011.
-
Abstract
- Dominic J Allocco, Anita A Joshi, Keith D DawkinsBoston Scientific Corporation, Natick, MA, USAAbstract: Everolimus-eluting stents (EES) have become the most commonly implanted coronary stents worldwide. This review describes and analyzes the clinical data supporting the use of EES, focusing primarily on published, randomized, controlled trials. Everolimuseluting stents have been shown to have less restenosis, stent thrombosis, and periprocedural myocardial infarction compared with earlier generation paclitaxel-eluting stents (PES). Lower rates of adverse events for EES compared with PES were generally seen in all subgroups, with the notable exception of patients with diabetes mellitus. There have been fewer, randomized, clinical trials comparing EES with either sirolimus-eluting stents or zotarolimus-eluting stents, although very good results with EES have been observed in the trials that have been performed. Recent clinical trial data suggest that this excellent safety and efficacy profile is maintained in a next-generation EES designed to have improved mechanical properties and radiopacity.Keywords: drug-eluting stents, everolimus, Xience V, Promus, Promus ElementVideo Abstract: http://dvpr.es/allocco
- Subjects :
- Medical technology
R855-855.5
Subjects
Details
- Language :
- English
- ISSN :
- 11791470
- Volume :
- 2011
- Issue :
- default
- Database :
- Directory of Open Access Journals
- Journal :
- Medical Devices: Evidence and Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9f0486b7a1564f68bdeed40109681f26
- Document Type :
- article