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Childhood adiposity, serum metabolites and breast density in young women

Childhood adiposity, serum metabolites and breast density in young women

Authors :
Joanne F. Dorgan
Heather J. Baer
Kimberly A. Bertrand
Erin S. LeBlanc
Seungyoun Jung
Laurence S. Magder
Linda G. Snetselaar
Victor J. Stevens
Yuji Zhang
Linda Van Horn
Source :
Breast Cancer Research, Vol 24, Iss 1, Pp 1-11 (2022)
Publication Year :
2022
Publisher :
BMC, 2022.

Abstract

Abstract Background Childhood adiposity is inversely associated with young adult percent dense breast volume (%DBV) and absolute dense breast volume (ADBV), which could contribute to its protective effect for breast cancer later in life. The objective of this study was to identify metabolites in childhood serum that may mediate the inverse association between childhood adiposity and young adult breast density. Methods Longitudinal data from 182 female participants in the Dietary Intervention Study in Children (DISC) and the DISC 2006 (DISC06) Follow-Up Study were analyzed. Childhood adiposity was assessed by anthropometry at the DISC visit with serum available that occurred closest to menarche and expressed as a body mass index (BMI) z-score. Serum metabolites were measured by untargeted metabolomics using ultra-high-performance liquid chromatography–tandem mass spectrometry. %DBV and ADBV were measured by magnetic resonance imaging at the DISC06 visit when participants were 25–29 years old. Robust mixed effects linear regression was used to identify serum metabolites associated with childhood BMI z-scores and breast density, and the R package mediation was used to quantify mediation. Results Of the 115 metabolites associated with BMI z-scores (FDR

Details

Language :
English
ISSN :
1465542X
Volume :
24
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Breast Cancer Research
Publication Type :
Academic Journal
Accession number :
edsdoj.9eed5e334011455c98c416ae83c14db8
Document Type :
article
Full Text :
https://doi.org/10.1186/s13058-022-01588-y