Airway reactivity to mannitol is similarly increased in chronic cigarette and water pipe smokers

Andreas Scherr, Jerome Schmidlin, Silvio Albisser, Michael Tamm, Daiana Stolz Clinic for Pneumology and Respiratory Cell Research, University Hospital of Basel, Basel, Switzerland Background: In contrast to cigarette smoking, the association between water pipe smoking and airway hyperresponsiveness remains widely unexplored.Methods: A bronchoprovocation challenge with mannitol was performed in young adults recruited at the University of Basel, Switzerland. Subjects were categorized as acute water pipe smokers (single episode of water pipe smoking, no or