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The Blockade of Glutamate N-methyl-D-aspartate Receptors into the Prelimbic of Prefrontal Cortex Decreases Morphine-induced Conditioned Place Preference in Rat

The Blockade of Glutamate N-methyl-D-aspartate Receptors into the Prelimbic of Prefrontal Cortex Decreases Morphine-induced Conditioned Place Preference in Rat

Authors :
Samad Javadi
Hojjatallah Alaei
Ebrahim Hosseini
Mohammad Amin Edalatmanesh
Source :
Indonesian Biomedical Journal, Vol 9, Iss 3, Pp 165-72 (2017)
Publication Year :
2017
Publisher :
Secretariat of The Indonesian Biomedical Journal, 2017.

Abstract

BACKGROUND: The prelimbic area (PL) of the prefrontal cortex is susceptible to abnormal developmental stimuli that raises the risk of addiction. Glutamate receptors play a key role in opiate reinforcement and reward functions in this area. Therefore, we examined the effect of the DL-2-amino-5-phosphonopentanoic acid (AP5), as N-methyl-D-aspartate (NMDA) receptor antagonist into the PL on the phases of conditioned place preference (CPP) induced by morphine. METHODS: Male Wistar rats were divided into 12 groups (3 surgical groups for each dose of morphine in any phase of CPP) and anaesthetized with chloral hydrate. Cannula was implanted into the PL and the AP5 was injected into this area and morphine-induced CPP was investigated. Data were processed with the commercially available SPSS 22 software using one-way ANOVA and Tukey's test. p

Subjects

Subjects :
Medicine (General)
R5-920

Details

Language :
English
ISSN :
20853297 and 23559179
Volume :
9
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Indonesian Biomedical Journal
Publication Type :
Academic Journal
Accession number :
edsdoj.9e9061c40ed94fa7838a1f8f6f02b491
Document Type :
article
Full Text :
https://doi.org/10.18585/inabj.v9i3.343