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HLA-DRB1 is associated with cefaclor-induced immediate hypersensitivity
- Source :
- World Allergy Organization Journal, Vol 17, Iss 5, Pp 100901- (2024)
- Publication Year :
- 2024
- Publisher :
- Elsevier, 2024.
-
Abstract
- Background: Drug-induced hypersensitivity such as anaphylaxis is an important cause of drug-related morbidity and mortality. Cefaclor is a leading cause of drug induced type I hypersensitivity in Korea, but little is yet known about genetic biomarkers to predict this hypersensitivity reaction. We aimed to evaluate the possible involvement of genes in cefaclor induced type I hypersensitivity. Methods: Whole exome sequencing (WES) and HLA genotyping were performed in 43 patients with cefaclor induced type I hypersensitivity. In addition, homology modeling was performed to identify the binding forms of cefaclor to HLA site. Results: Anaphylaxis was the most common phenotype of cefaclor hypersensitivity (90.69%). WES results show that rs62242177 and rs62242178 located in LIMD1 region were genome-wide significant at the 5 × 10−8 significance level. Cefaclor induced type I hypersensitivity was significantly associated with HLA-DRB1∗04:03 (OR 4.61 [95% CI 1.51–14.09], P
Details
- Language :
- English
- ISSN :
- 19394551
- Volume :
- 17
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- World Allergy Organization Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9e7d978eac1246b4a3646cb3e8663b81
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.waojou.2024.100901