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Hemoglobin Oxidation Reactions in Stored Blood

Authors :
Abdu I. Alayash
Source :
Antioxidants, Vol 11, Iss 4, p 747 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Hemoglobin (Hb) inside and outside the red blood cells (RBCs) undergoes constant transformation to an oxidized form in a process known as autoxidation. The ferrous heme iron (Fe2+) of the prosthetic group is spontaneously transformed into an oxidized ferric (Fe3+) form, but under oxidative stress conditions a higher oxidation ferryl heme (Fe4+) is also formed. Although Fe3+ is a non-functional form of Hb, the Fe4+ is also extremely reactive towards other biological molecules due to its high redox potential. The RBC contains an effective reductive machinery that maintains Hb in the functional form with little oxidation during its life span. The redox transformation of Hb occurs to a lesser extent in young RBCs; it may, however, have detrimental effects on the integrity of these cells during ex vivo storage or when RBCs are subjected to pathogen reduction processes. In this review, Hb oxidation reactions (“oxidative lesion”) will be described, including details of how these reactions might impact the clinical use of stored or processed blood for therapeutic purposes.

Details

Language :
English
ISSN :
20763921
Volume :
11
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Antioxidants
Publication Type :
Academic Journal
Accession number :
edsdoj.9e1b8925ac3b4de4804b89a204b2e51f
Document Type :
article
Full Text :
https://doi.org/10.3390/antiox11040747