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CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease

Authors :
Emmanouela Tsagkaraki
Sarah M. Nicoloro
Tiffany DeSouza
Javier Solivan-Rivera
Anand Desai
Lawrence M. Lifshitz
Yuefei Shen
Mark Kelly
Adilson Guilherme
Felipe Henriques
Nadia Amrani
Raed Ibraheim
Tomas C. Rodriguez
Kevin Luk
Stacy Maitland
Randall H. Friedline
Lauren Tauer
Xiaodi Hu
Jason K. Kim
Scot A. Wolfe
Erik J. Sontheimer
Silvia Corvera
Michael P. Czech
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Worldwide pandemics of obesity and diabetes prompt an urgent need for new approaches to their prevention and cure. Here the authors present a CRISPR-based strategy that enhances the therapeutic potential of human adipocytes when implanted in obese mice.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.9db95209ec9c4296b7f96552abbf9db0
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-27190-y