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Association analysis of polymorphisms in STARD6 and near ECHDC3 in Alzheimer’s disease patients carrying the APOE ε4 Allele

Authors :
Yin J
Feng W
Yuan H
Yuan J
Wu Y
Liu X
Jin C
Cheng Z
Source :
Neuropsychiatric Disease and Treatment, Vol Volume 15, Pp 213-218 (2019)
Publication Year :
2019
Publisher :
Dove Medical Press, 2019.

Abstract

Jiajun Yin,1 Wei Feng,2 Hongwei Yuan,3 Jianmin Yuan,1 Yue Wu,3 Xiaowei Liu,3 Chunhui Jin,1 Zaohuo Cheng3 1Brain Science Basic Laboratory, The Affiliated Wuxi Mental Health Center with Nanjing Medical University, Wuxi, Jiangsu Province, China; 2Department of Social Prevention and Control, The Affiliated Wuxi Mental Health Center with Nanjing Medical University, Wuxi, Jiangsu Province, China; 3Department of Geriatric Psychiatry, The Affiliated Wuxi Mental Health Center with Nanjing Medical University, Wuxi, Jiangsu Province, China Background and purpose: Lipid metabolism plays an important role in Alzheimer’s disease (AD), and recent evidence suggests that single nucleotide polymorphisms (SNPs) in the StAR-related lipid transfer domain 6 (STARD6) and near the enzyme enoyl CoA hydratase domain containing 3 (ECHDC3) gene are related to plasma lipid levels or lipid traits in AD. Materials and methods: To identify whether the variants in or near the STARD6 and ECHDC3 genes contribute to AD susceptibility, we carried out an association analysis of STARD6 rs10164112 and ECHDC3 rs7920721 in combination with the apolipoprotein E (APOE) ε4 allele in a case–control study (278 cases, 509 controls) in China. Results: We identified that SNP rs10164112 in the STARD6 gene was a risk factor associated with AD and the APOE ε4 carriers (all P

Details

Language :
English
ISSN :
11782021
Volume :
ume 15
Database :
Directory of Open Access Journals
Journal :
Neuropsychiatric Disease and Treatment
Publication Type :
Academic Journal
Accession number :
edsdoj.9d9bfcde1b9440aea78bc7f0097f54fd
Document Type :
article