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The characteristics and risk factors of cerebrovascular events in young systemic lupus erythematosus patients: A case-control study
- Source :
- Journal of the Formosan Medical Association, Vol 123, Iss 4, Pp 478-486 (2024)
- Publication Year :
- 2024
- Publisher :
- Elsevier, 2024.
-
Abstract
- Objectives: We clarified the characteristics and risk factors of CVEs in young SLE patients. Method: We retrospectively reviewed the medical records of patients younger than 50 years of age diagnosed with SLE and first CVEs from 1995 to 2020 in a tertiary medical center in Taiwan. We collected data on the patient characteristics before the CVE and reviewed the laboratory data obtained during the period. At a ratio of 1:3, cases and controls were matched with sex, SLE diagnosis age, diagnosis year, and SLE duration. Results: We enrolled 43 CVE SLE patients and matched 129 non-CVE SLE controls. The median age at the time of the CVE was 39 years. Around 70% of young-aged CVE involved the cerebral lobes of frontal (∼30%), parietal (∼20%), occipital (∼10%), and temporal (∼10%). The peak incidence period for hemorrhagic CVE was within 1st year of SLE diagnosis (37%); in contrast, during the 2nd to 5th year of SLE diagnosis (25%) for ischemia CVEs. Hyperlipidemia (odds ratio [OR] = 19.36, p = 0.002), anti-phospholipid syndrome (APS) (OR = 41.9, p = 0.0068), a lower hemoglobin level (OR = 0.66, p = 0.0192), and a higher SLE Disease Activity Index (SLEDAI-2k) score (OR = 1.22, p = 0.0019) were independent risk factors for CVEs in young SLE patients. Conclusion: Hyperlipidemia, APS, low Hb level, and high SLEDAI-2k significantly increase the risk of young-aged SLE patients developing CVE.
- Subjects :
- APS
Cerebrovascular events
Hyperlipidemia
Risk factors
SLE
Medicine (General)
R5-920
Subjects
Details
- Language :
- English
- ISSN :
- 09296646
- Volume :
- 123
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of the Formosan Medical Association
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9d9878f319d458ab17d20e462ada24f
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jfma.2023.09.018