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Pig genome functional annotation enhances the biological interpretation of complex traits and human disease

Authors :
Zhangyuan Pan
Yuelin Yao
Hongwei Yin
Zexi Cai
Ying Wang
Lijing Bai
Colin Kern
Michelle Halstead
Ganrea Chanthavixay
Nares Trakooljul
Klaus Wimmers
Goutam Sahana
Guosheng Su
Mogens Sandø Lund
Merete Fredholm
Peter Karlskov-Mortensen
Catherine W. Ernst
Pablo Ross
Christopher K. Tuggle
Lingzhao Fang
Huaijun Zhou
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Annotating functional elements of the genome helps the interpretation of genetic variation. Here, the authors compile functional genomics data for the pig genome over 14 tissues with 15 different chromatin states, integrate the data with WGS and GWAS data, and compare conservation of regulatory elements across mouse and human tissues.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.9d93bfd836f04f2482675331b406ee47
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-26153-7